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J Musculoskelet Pain 10 : 215220 Riedel W et al

doi: 10.1097/MED.0000000000000190 6 EspositoDRotondiMAccardoGValloneGConzoGDocimoGet al

By activating pro-apoptotic signaling pathways (e.g., caspase, p53), ROS induces chondrocyte death, diminishing cell survival and repair capacity

Meanwhile, the significant role of intestinal permeability has been highlighted in PD, which lays the groundwork for novel PD therapy targeting the restoration of the intestinal barrier