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In general, payload release occurs in the TME or after cellular internalization within endosomal/lysosomal compartments, and in some systems may further proceed following endosomal escape, thereby determining the cytosolic availability of the active degrader [184,185,186]

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We observed a decrement in protein content and activity of CSE, a major enzymatic source of endogenous H 2 S, in the corpus cavernosum of mice following 12 weeks of a westernized diet high in sucrose and fat derived from saturated and -6 polyunsaturated fatty acids

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