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In addition, lipid nanoparticles encoding the tumor-associated antigens gp100 and TRP2 mRNA can also induce CD8 + T cell activation thereby shrinking tumors and prolonging the overall survival of treated mice (146)

Significance was determined by one-way repeated measures analysis of variance, and the HolmSidak method for multiple comparisons versus the control group, using SigmaPlot 10.0 software (Systat Software, San Jose, CA, USA)