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ED is often present in up to half of the cases (8%52%), and Dupuytrens contracture is reported in 4% to 26% of patients [13,14,15]

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To date, clinical trials investigating the effectiveness of NAC demonstrate that the oral coupled with intravenous administration of NAC increases the expression of the dopamine transporter and shows modest improvement in UPDRS scores in PD patients 158,159

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