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In patients with WD with reproductive dysfunction, engineered extracellular vesicles delivering a copper-chelating ligand significantly reduced non-ceruloplasmin-bound copper (42.7%) and urinary copper (47.7%), normalized gonadotropin levels in 87.5% of patients and exhibited a favorable safety profile (6.25% mild gastrointestinal events) (231)

doi: 10.1523/JNEUROSCI.0860-10.2010 145 TanseyM

doi: 10.3389/fphar.2026.1759824 Received 03 December 2025 Revised 27 February 2026 Accepted 23 March 2026 Published 17 April 2026 Corrected 12 June 2026 Volume 17 - 2026 Edited by Xiaoxin Wang, Georgetown University Medical Center, United States Reviewed by Yunwen Yang, Nanjing Childrens Hospital, China Jn li, Army Medical University, China Updates Copyright 2026 Han, Zhang, Li, Zhang, Shen, Zhang, Xu, Zhou and Wang

The ability of silver to target multiple pathways also lowers the propensity of resistance acquisition by microbes, which is commonly observed among antibiotics with single targets (25)