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Phosphatidylethanolamine containing two fatty acyl groups of ACSL4 activated arachidonic and adrenergic acyl groups has been shown to be the death signal of ferroptosis (Zhang et al., 2022)

Oxidation of glucose and pyruvate, however, generates ATP by both substrate level and oxidative phosphorylation, generating more ATP per oxygen consumed

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mTORC1 regulates cystine uptake through ATF4 Among the 61 shared mTORC1- and ISR-induced ATF4 gene targets identified, the cystine-glutamate antiporter Slc7a11 (xCT) was the most significantly induced gene upon insulin treatment (Figure 1F)