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doi: 10.1016/j.brainresbull.2008.12.001 Summary Keywords bilirubin, dopaminergic neurons, inflammation, neurodevelopment, oxidative stress, Parkinson's disease Citation Zhang Y, Liu H, Cao H, Deng M, Han Z, Wu X, Wan Q, Wang R, Xu Y, Lai J, Jiang Y, Gong L, Liu Z, Lai K and Shi H (2026) Neuroprotective role of bilirubin in Parkinson's disease

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Specifically, the protein ankyrin repeat and SOCS box protein 1 (ASB1) (a substrate-recognition subunit of an E3 ubiquitin ligase complex) binds to SQOR and mediates K48-linked ubiquitination of SQOR, targeting it for proteasomal degradation