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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions

(2) POIs must at least temporally localize to the nucleus or cytosol, the compartments with high activity of the N-end rule pathway orin case for membrane localized proteinshave accessible N termini 13