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Zinc deficiency aggravates oxidative stress leading to inflammation and fibrosis in lung of mice

10.1016/j.biopha.2018.03.007 100 KhanN.MukhtarH

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate