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Description

It was first discovered in the 1970s in the hypothalamus and is named for its ability to promote delta wave sleep, the deep, restorative stage of sleep crucial for memory consolidation, immune function, and overall recovery

The transferrin protein binds to the transferrin receptors on the barrier which carry it across

For example, the compound 13 (racemic) is a very week IRAP inhibitor (Lukaszuk et al., 2011) and compound 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) (Andersson et al., 2008)