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Indeed, the initial Orange Book proposal described efforts by drug companies and medical societies to confuse the public about therapeutic equivalents, with claims that special coatings or fillers caused proprietary drugs to be more effective than generics

van Schouwenburg et al., 2010

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Protein spots were excised from the gels and sent to the Department of Neuroplasticity of Shinshu University Graduate School of Medicine in Japan for LC-MS/MS analysis