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Figure 2 4.1 Key molecular pathways related to neuroinflammation-mediated ferroptosis 4.1.1 Cyclic GMP-AMP synthase/stimulator of interferon genes The stimulator of interferon genes (STING) pathway is activated by double-stranded DNA (dsDNA), which activates the expression of interferon (IFN) via interferon regulatory factor 3 (IRF3) (Liu et al., 2015)

They exert profound systemic effects due to their extremely high receptor affinity and the subsequent intracellular amplification of their signal

Vitamin E is a major chain-breaking antioxidant and is the first line of defense against lipid peroxidation by protecting cell membranes during the early stages of free radical attack [48]

This may suggest that a different mechanism is at play, which could relate to the abnormal immune response present in ME/CFS (311)