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Generated ROS during MTX administration provoke DNA damage and induce apoptosis via activating intrinsic apoptotic pathways, as documented in various studies (Koppelmann et al., 2012

In addition, the authors investigated sex differences in the distribution of mercury chloride by comparing their results to a previous study with male mice (Nielsen & Andersen, 1989)

As shown in Figure 5, meta-analysis demonstrated no statistically significant difference in adverse event incidence between curcumin and placebo groups (OR = 0.03, 95% CI: 0.03 to 0.09