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On the other hand, GSTP-knocked out colon cancer cell HCT116 has been reported to display proliferation impairment, with doubling time increased to 5 times that of normal cells due to oxidative stress state under the growth-limiting condition 45

Biochemical analyses establish AMPK as a central regulator of mitochondrial biogenesis through direct modulation of lipid oxidation

Interestingly, the mutant also shows an overexpression of TAG-degrading lipase genes, and the intracellular lipolytic enzymes mediate TAG hydrolysis for their utilization as energy source