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Description

P., Gerwig, G

Methylation at R248 inhibits MDH1 post-translational mechanisms by disrupting MDH1 dimerization, which modulates mitochondrial respiration and glutamine-dependent production of NADPH in pancreatic cancer cells

This regulatory effect weakens the mitochondrial response to oxidative stress, thereby enhancing antioxidant capacity and offering effective protection for photoreceptor cells against light-induced retinal damage