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Vitamin B12 is a water-soluble vitamin, which means that excess amounts are flushed out of the body through the urine, making a vitamin B12 overdose nearly impossible

The band corresponding to free DNA disappears, but the band corresponding to tetrasomes shows slightly decreased intensity with the addition of CENP-C CR

Int J Mol Sci 22(22):12245

Notably, it has been reported that the upregulation of HSP70 is closely linked to cuproptosis, and HSP70 is a crucial factor in activating innate immune response and aggravating the pathological changes in vitiligo (60, 61)