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Mutations in parkin ( PRKN ) or phosphate and tensin homolog-induced kinase 1 ( PINK1 ) prevent cells from responding to mitochondrial damage by altering the balance of fusion to fission and disrupting mitophagy, which leads to familial forms of PD [97, 98]

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Sherer et al., 2003, Fornai et al., 2005) which are sharing the same KEs with this AOP but are caused by a different MIE

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