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In this overview, promotor hypermethylation of multiple genes was described, for instance hypermethylation of RASSF1A and CDKN2A, both being tumor suppressor genes involved in regulating cell cycle arrest, apoptosis and/or senescence

The disease results from the co-inheritance of a -thalassemia allele and hemoglobin E, the most prevalent structural -globin variant in Southeast Asia

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Expression levels of Sertoli cell markers, such as Sox9 , Anti-Mullerian Hormone ( AMH ), and Wilms tumor gene1 ( WT1 ) were significantly reduced in the DZN-treated group, with Sox9 , AMH , and WT1 decreasing by 1.47, 0.75, and 1.28 (log2 scales), respectively, compared with the control group (Fig