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Yamatsu K, Kaneko T, Kitahara A, Ohkawa I

Critically, and unlike full hGH, AOD-9604 did not raise blood glucose or suppress insulin, and it does not bind the hGH receptor or the IGF-1 pathway[2] separating fat metabolism from growth-hormone side effects

The first two clinical studies in which LVs were used to transduce HSCs for the treatment of -thalassemia [170] and adrenoleukodystrophy [175] showed that one key restriction to fully effective treatment was the limited efficacy of stem cell transduction, which was only 1020%