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(124) reported a 4-5 fold increase in GPX mRNA level in cultured myotubes in response to paraquat, H 2 O 2 and menadione treatment, supporting the above notion

These functional isoforms differ in their translation start site, resulting in length variations, with isoform A consisting of 222 amino acids and isoform X1 containing 264 amino acids, including an additional 42 amino acid segment at the N-terminus

In addition, the inhibitory effect of vitamin K1 on ferroptosis is mediated among cells, suggesting that vitamin K1 may be effective in the treatment of other ferroptosis-related diseases

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