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By suppressing cytotoxic CD8+ T-cells, expanding regulatory T cells, and promoting myeloid-derived suppressor cells (MDSCs), VEGF facilitates tumor immune evasion ( The VEGF signaling axis is heterogeneous, comprising multiple ligands (VEGF-A, -B, -C, -D, and placental growth factor) and receptors (VEGFR-1, -2, -3) as well as co-receptors such as neuropilins ( + T cells, expanding regulatory T cells, and increasing myeloid-derived suppressor cells (MDSCs), VEGF promotes tumor immune evasionmechanisms corroborated in translational studies and consistent with the synergy observed when VEGF blockade is combined with immune checkpoint inhibitors (Figure 1)

Gestrelius S, Andersson C, Johansson AC, Persson E, Brodin A, Rydhag L, et al

This may support nutrient and oxygen supply to reproductive tissues