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As opposed to PCD, SCD occurs due to, or in association with, other disorders such as liver or kidney disease, defects in fatty acid metabolism, or administration of pharmacological agents such as pivampicillin or valproic acid (discussed below) [27, 41, 42]

Nat Rev Dis Primers 4 , 13 (2018)

Nowadays, the most common cause of systemic complications and cirrhosis of the liver is known to be induced by MASLD, which usually starts with lipid droplet accumulation within hepatocytes, causing lipotoxicity and inflammation, magnified according to the genetic susceptibility of affected individuals

Clinical Epigenetics , 17 (1), 4