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(2025) Abbreviations 5-ALA: 5-Aminolevulinic Acid ALAD: Delta Aminolevulinate Dehydratase ALAS: 5-Aminolevulinate Synthase CAFs: Cancer-associated Fibroblasts CD44: Cluster of Differentiation 44 CPOX: Coproporphyrinogen Oxidase DFO: Deferoxamine DFX: Deferasirox DMT1: Divalent Metal Transporter 1 ETC: Electron Transport Chain FBXL5: F-box and Leucine-rich Repeat Protein 5 FECH: Ferrochelatase FLVCR: Feline Leukaemia Virus Subgroup C Receptor FPN: Ferroportin FT: Ferritin HCP1: Heme Carrier Protein 1 HIF-1: Hypoxia-inducible Factor 1-alpha HMBS: Hydroxymethylbilane Synthase HMOX: Heme Oxygenase iCAFs: Inflammatory CAFs IL-6: Interleukin-6 IREs: Iron-Responsive Elements IRPs: Iron Regulatory Proteins ISC: Iron-sulfur Cluster iTAMs: Iron-rich TAMs LCN2: Lipocalin 2 LIP: Labile Iron Pool Mfrn1/2: Mitoferrin 1/2 mitoDFO: Mitochondrially Targeted DFO mitoDFX: Mitochondrially Targeted DFX NCOA4: Nuclear Receptor Coactivator 4 NDRG1: N-myc Downstream-regulated Gene 1 NKs: Natural Killer OXPHOS: Oxidative Phosphorylation PCBP: Poly(rC) Binding Protein PDAC: Pancreatic Ductal Adenocarcinoma PPOX: Protoporphyrinogen Oxidase STEAP3: Six-transmembrane Epithelial Antigen of the Prostate 3 TAMs: Tumor Associated Macrophages TCA: Tricarboxylic Acid TfR1: Transferrin Receptor 1 TME: Tumor Microenvironment UROS: Uroporphyrinogen III Synthase UROD: Uroporphyrinogen Decarboxylase References Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM

This information is intended to be informational and educational only and should not replace or complement medical advice.