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There are several underlying mechanisms that have been implicated in this age-related muscle wasting: decreased protein synthesis, reduced enzymatic activity (especially in glycolytic and glycogenolytic pathways), depletion in energy reserves, increased oxidative damage, and changes in ion content[351], among others

Intestinal epithelial AMPK deficiency causes delayed colonic epithelial repair in DSS-induced colitis

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Oligomeric -synuclein exerts neurotoxic effects through mitochondrial dysfunction, glial cell inflammatory response, lysosomal dysfunction and so on