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Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)

Another commenter voiced concern about establishing restrictive time limits for physicians/NPPs to make POC modifications since none exist currently and they recommend we maintain standing policy until more input is gathered from stakeholders

Brain Behav Immun (2015) 48:16573

I too have increasing joint stiffness and muscle spasms but I'm not sure that this is linked to the actual B12 injections