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Ruiz-LopezMFreitasMEOliveiraLMMunhozRPFoxSHRohaniMet al

These residues form hydrophobic interactions with the methyl groups, while the carbonyl O of P124 hydrogen bonds with the nitrogen atom, which conforms to a tetrahedral configuration suggesting that it is protonated

It follows due to the up-regulation of various transcriptional factors such as NF-B, ETS proto-oncogene 1 (ETS-1, transcription factor), TWIST, activator protein 1 (AP-1), Snail and zinc finger E-box binding (ZEB)