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However, administration of PJ, CM, CM and SM markedly decreased liver and serum TG contents

Even if the peptide does not directly bind to Cu, covering His residues (such as His259 and His263) will destroy the stable coordination of Cu and reduce its catalytic efficiency (Joompang et al., 2020)

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Anti-sense nucleotides (ASOs) have demonstrated promise in lowering RNA foci and their deleterious effects and ASOs are under clinical trials for ALS treatment ( 3.2 Alzheimer's disease (AD) AD is a progressive ND characterized by neurofibrillary tangles produced by tau proteins as well as a buildup of amyloid plaques ( However, recent investigations of alternative therapies for AD have sparked interest in compounds with disease-modifying capability, one such molecule, a natural polyphenol, is curcumin, which has anti-inflammatory and antioxidant properties (Table 1)