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We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig

And maybe produce symptoms and you might feel better at best, which is why we're calling it bandaid therapy

In addition, DMB significantly attenuated but did not completely eliminate pulmonary artery AS induced by an 8-week exposure to intermittent hypoxia and hypercapnia (IHC) in ApoE / mice and Ldlr / mice (Xue et al., 2017)