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Ackermann P, Hetz S, Dieckow J, Schicht M, Richter A, Kruse C,

Open Access ARTICLE C-PhycocyaninCisplatin Combination Targeting Redox Balance for Enhanced Efficacy Against Glioblastoma Cells 1 Laboratory of Genetics Immunology and Human Pathology, Biology Department, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, 2092, Tunisia 2 Facult des Sciences Mdicales et Paramdicales, Institut de NeuroPhysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Universit, Marseille, 13005, France 3 Confocal Microscopy Unit, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, 1007, Tunisia 4 Laboratory of Neurophysiology, Cellular Physiopathology and Biomolecules Valorisation, LR18ES03, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, 2092, Tunisia * Corresponding Authors: Herv Kovacic

Low Met levels lead to a decrease of hepatic SAMe, releasing its inhibition on BHMT and MTHFR, which promotes the synthesis of Met to restore normal levels of Met