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Bender and Cooksey, 1993

Mechanism of Folate Deficiency-mediated Neurodegeneration The precise mechanisms by which folate deficiency contribute to neurodegeneration remain unclear, though it is largely attributed to disruptions in OCM

Bonaca MP, Catarig AM, Houlind K, et al

Although TSH shows a logarithmic amplification in response to minor changes in FT4 and free triiodothyronine (FT3), it reflects pituitary thyroid hormone sensitivity but may not accurately represent peripheral thyroid hormone activity ( Third, the autoimmune nature of Hashimotos thyroiditis may itself contribute significantly to persistent symptoms, even when thyroid hormone levels are within the reference ranges ( In light of these mechanisms, the prevailing assumption that biochemical euthyroidism equates to clinical remission in HT should be challenged, highlighting the need to broaden the clinical framework beyond hormone levels to include markers of immune activity, inflammation, and patient-reported outcomes