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As a by-product of cell metabolism, ROS is produced during normal aerobic metabolism and plays an important signaling role within cells, capable of reversibly oxidizing key reduction-oxidation (REDOX) sensitive cysteine residues on target proteins, and these oxidative post-translational modifications (PTM) can control the biological activity of many enzymes and transcription factors (TFs) (Hua et al., 2024

We next asked whether the different impacts of impairing the glutathione and thioredoxin pathways are specific to yeast or also hold true in other eukaryotic systems

doi: 10.1042/BJ20100960

Hoebers FJP, Pluim D, Verheij M, Balm AJM, Bartelink H, Schellens JHM et al