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noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]

13 The increased burden of reactive oxidants in patients with COPD also derives from leukocytes and macrophages involved in the inflammatory process in the lungs

The copper ion is essential for biological activity the apo-peptide (GHK without copper) shows markedly reduced activity in most assay systems