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Fortunately, many modern radiation therapy techniques such as intensity-modulated radiation therapy (IMRT), helical tomotherapy, and volumetric-modulated arc therapy target cancerous tissue more precisely, reducing damage to nearby tissues and organs (Chi 2013)

Sub-Nanometre Sized Metal Clusters: From Synthetic Challenges to the Unique Property Discoveries

In breast tumor cells, HA activation of CD44 leads to the expression of multidrug resistance gene (P-glycoprotein) and anti-apoptotic gene Bcl expression, which promotes tumor cell proliferation and survival [30]

And these components physically interact with a large number of target proteins in the cytoplasm and nucleus (Srinivasan et al., 2007