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Most children with GDH-HI have hyperammonemia, with blood ammonia levels are 25 times above the upper limit of normal

Steady-state optimization begins within days and lasts 35 months

10.1016/j.colcom.2024.100774 232 ZhangJ.TongD

Targeting TXNRD1 maintains efficacy of first-line therapy in vivo SCLC patients typically show high initial response rates to cisplatin-based chemotherapy, followed by relapse shortly after completing first-line therapy