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The development of MASLD occurs in a coordinated fashion and was proposed earlier as a two-hit hypothesis ( de novo lipogenesis (DNL) in the liver which increases the insulin resistance (Figure 1) ( However, at present it is referred as the multi-hit hypothesis as the development and progression of the disease arises from a combination of factors that are interconnected and contribute to the advancement of the disease

vitamin C, vitamin E, glutathione or coenzyme Q10) to their original active form and increases their effectiveness detoxifies the body by forming complexes with (heavy) metals such as cadmium, iron, copper or mercury Alpha lipoic acid has also been used successfully for years in medicine for various diseases such as diabetes, nerve damage or Alzheimer's disease: The substance not only has an "only" antioxidant effect, but also inflammatory, anticarcinogenic, pain-reducing and neuroprotective and increases insulin sensitivity