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10.1016/j.tiv.2014.01.004 Toxicol Vitro

Ibraheem, A

Concurrently, HIF-1 inhibits oxidative phosphorylation by upregulating NADH dehydrogenase (ubiquinone)-1 subcomplex 4-like 2 (NDUFA4L2) [323]

The idea is that even if the peptide is broken down before it reaches the bloodstream, it might exert some beneficial actions on the gut's epithelial cells during its passage