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This leads to damage to tissue cells, including vascular ECs (Incalza et al., 2018), adipocytes (Furukawa et al., 2004), and pancreatic -cells (Gerber and Rutter, 2017)

It may possibly support lean muscle retention

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The unaffected CD38 binding of CD3813 in the presence of excess cold daratumumab suggests that CD3813 and daratumumab have distinct binding sites on CD38 [110]