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However, no significant differences in serum IGF-1 were seen among those who restricted calories after two years

Additionally, another line of evidence which has shown that GA-AGE is involved in neurodegeneration, is that the neurotoxic effects of serum AGE fractions from diabetic nephropathy in haemodialysis patients were completely attenuated by the addition of an anti-GA-AGE antibody, but not by antibodies against other types AGEs (30)