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Furthermore, studies have found that HDAC (histone deacetylase), epigenetic regulators that remove acetyl groups from histones, are closely associated with endothelial dysfunction, inflammation, and myocardial fibrosis through their epigenetic regulatory actions (Jin et al., 2017a)

Acknowledgements We thank the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants numbers 2016/07870-9 and 2021/04977-5 (G.H.G.) and the Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) grant numbers 301058/2019-9 and 404735/2018-5 (G.H.G.), both from Brazil, and the National Institutes of Health/National Institute of Allergy and Infectious Diseases grant R01AI153356 (GHG) from the USA

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