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10.1016/S0006-8993(02)03674-0 Brain Res

19, the liver and kidneys exhibited higher normalized dosage distribution of Cu 5.4 O USNPs, reaching 7.92 and 7.97 %ID g 1 respectively, while the distributions of NPs in the heart, spleen, lung, and blood reached 2.25, 5.07, 3.02, and 2.84 %ID g 1 , respectively

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Rather than treating ferroptosis as a uniform vulnerability, clinical translation will probably succeed where patients can be stratified by (1) the architecture of antioxidant defenses (for example, FSP1/GPX4 balance), (2) the size and distribution of cellular CoQ pools, (3) lipid composition and peroxidation-prone membranes and (4) oncogenic programs that remodel redox metabolism (such as NRF2KEAP1)