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An aliquot of synaptosomal suspension (200 l) was added to 800 l incubation medium B having pH 7.4, 7.0, 6.0 or containing 50 M of 1-chloro-2,4-dinitrobenzene (CDNB)

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Zhou Y.T., He W., Lo Y.M., Hu X., Wu X., Yin J.J

Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function