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Stool hardness and anal bleeding were classified into three categories according to the following criteria: Stool hardness was classified according to the shape of the stool (shaped stool, unformed stool, and liquid stool) and the presence or absence of stool adhesion to the anus, and anal bleeding was classified according to the degree of bleeding (presence, absence, and slight adhesion)

Marchetto [email protected] These authors have contributed equally to this work

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Proc Natl Acad Sci USA 107 : 94409445