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NADPH-dependent disulfide reductases Although there are hundreds of different NADPH-dependent enzymes in biology, each of which has the ability to use electrons extracted from NADPH to reduce specific organic or inorganic substrates, only two small groups of these enzymes, the Trx-disulfide reductases (TrxRs) and the glutathione-disulfide (GSSG)-reductases (Gsrs), can reduce an intracellular disulfide [42]

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CORRESPONDING AUTHOR: Olivia Avidan MD Department of Internal Medicine Warren Alpert Medical School of Brown University Rhode Island Hospital Providence, RI 02903 Email: [email protected]

Rifaximin versus neomycin on hyperammoniemia in chronic portal systemic encephalopathy of cirrhotics