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21 reasoned that L-CYSee or its free radical cation 46 reversed the effects of morphine via its reductive capacity, which down-regulates ORs 47 or affects OR function by effects on membrane-associated proteins 48

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The magnitude of change in Hb A 1c was directly proportional to baseline values in the ARA 290 group, whereas no relationship was observed between baseline and posttreatment values in the placebo group (data not shown)

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