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Figure 2 4 Detection and diagnostic strategies for HGSOC drug resistance HGSOC is a highly aggressive and drug-resistant tumor, making research into its drug resistance mechanisms crucial for improving patient prognosis

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COMT converts DA to 3-methoxytyramine, which is then reduced to homovanillic acid (HVA) by MAO (Fig

GOT1 is a crucial enzyme in the aspartate-malate shuttle, generating pyruvate and boosting the NADPH/NADP + ratios which keep GSH levels low and redox homeostasis under check