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Brazil Scientific studies have found that the FOXO4-DRI peptide works by selectively inducing apoptosis in senescent cells through disruption of the interaction between FOXO4 and p53 (1)

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Metabolic Regulation and Energy Homeostasis Research Broader metabolic regulation research including studies on energy substrate utilisation, fatty acid oxidation, mitochondrial function in adipocytes, and the molecular basis of metabolic flexibility, has drawn on this compound as a research tool