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As an endogenous human tripeptide used topically for decades in skincare, GHK-Cu is generally regarded as well tolerated, with the most common issues being local irritation, redness, or contact sensitivity in susceptible individuals

However, similar to other chronic diseases such as T2D, the focus in obesity management (including pharmacotherapy prescription) over time will need to be shifted to primary care and collaborative integrated care models to be developed between specialist obesity services and primary care striving to meet the needs of people living with obesity [115]

Nat Med 31 , 16981711 (2025)

10.1199/tab.0142 10 Ohkama-OhtsuN.OikawaA.ZhaoP.XiangC.SaitoK.OliverD