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The silymarin standard group displayed no histopathological alterations in most liver sections, with only a few binucleations of hepatocytes observed in some areas (Figures 11E, F), and apparent normal renal parenchyma, although some renal tubules exhibited mild vacuolar degeneration (Figures 12E, F)

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10.1093/nar/gks1193 8 BrownA

These studies indicate that 5-amino-1mq can delay skin fibroblast senescence by regulating NAD+ metabolism, providing a novel intervention target for skin anti-aging research