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doi: 10.1210/en.2004-0695 47 KirchnerHGutierrezJASolenbergPTPflugerPTCzyzykTAWillencyJAet al

aging can reduce regenerative output by altering which states persist and how efficiently cells transition between states

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This highly reactive product of lipid peroxidation contains 3 functional groups: (i) an electrophilic C = C double bond that is a Michael acceptor and that forms covalent adducts with nucleophilic amino acids, (ii) an aldehyde that can form Schiff base adducts with primary amines, and (iii) a hydroxyl group that can be oxidized to an electrophilic ketone [56]