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4 Potential role of mitochondrial dysfunction in RA-related immune-inflammation 4.1 Mitochondrial dysfunction affects immune-inflammatory pathways in RA 4.1.1 Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome pathway Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) is an intracellular receptor that senses foreign pathogens and endogenous danger signals, which assembles with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and Caspase-1 to form polymeric proteins known as NLRP3 inflammasomes

Cell 149 , 10601072 (2012)